Associate Scientist - Mass Spectrometry Proteomics

Company: Frederick National Laboratory for Cancer Research
Location: Frederick
Posted on: February 1, 2026

Job Description:

Associate Scientist - Mass Spectrometry Proteomics Job ID: req4472 Employee Type: exempt full-time Division: Cancer Research Technology Program Facility: Frederick: ATRF Location: 8560 Progress Dr, Frederick, MD 21701 USA The Frederick National Laboratory is operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases. Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way. PROGRAM DESCRIPTION The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise. KEY ROLES/RESPONSIBILITIES Work independently and collaboratively with scientists to perform liquid chromatography-mass spectrometry (LC-MS)-based proteomics experiments, including: protein extraction/digestion, solid-phase extraction (SPE), immunoaffinity enrichment, etc. following established SOPs Help operate and maintain state-of-the-art LC-MS instrumentation (SCIEX 7500, Thermo TSQ Altis, Thermo Orbitrap Eclipse) and ensure high quality data generation for targeted proteomics Perform comprehensive data analysis using a variety of methods and software, such as Skyline, Excel, R, Python, etc. Formally present data to team members and collaborators Establish (design, test, and write) new or modify/optimize existing technical SOPs Document experimental results in a reproducible manner Assist with everyday lab operation, including but not limited to: maintaining lab inventories, ordering supplies, receiving packages, maintaining lab waste, facilitating engineer visits, communicating lab activities to supervisor, etc. Comply with all safety procedures, company policies, and established ways of work in the group BASIC QUALIFICATIONS To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below: Possession of Bachelor’s degree from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) or four (4) years relevant experience in lieu of degree. Foreign degrees must be evaluated for U.S. equivalency In addition to the education requirement, a minimum of eight (8) years of related experience is required Both theoretical and hands-on experience in MS-based targeted (MRM and/or PRM) proteomics, including but not limited to: separation chemistry, sample preparation, LC-MS operation and troubleshooting, and data analysis Experience with performing large scale studies that require precise preparation (i.e., for quantitative work) Detail-oriented, highly-collaborative, self-motivated, and team-oriented Excellent verbal and written communication skills Ability to work on-site full time (8 hours/day, 5 days/week) Ability to obtain and maintain a security clearance PREFERRED QUALIFICATIONS Candidates with these desired skills will be given preferential consideration: M.S. degree in biochemistry, analytical chemistry or other related discipline from an accredited college or university according to the Council for Higher Education Accreditation 6 years of related post graduate MS-based proteomic experience Experience operating a SCIEX 7500 and/or Thermo TSQ Altis Experience operating a Waters ACQUITY UPLC M-Class, and/or Thermo UltiMate nanoLC (i.e., microflow or nanoflow LC, respectively) Experience with Skyline software Experience with Covaris ultrasonicators and/or liquid handlers Experience working with antibodies Experience performing global proteomics experiments Familiarity with CLIA requirements JOB HAZARDS This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations Commitment to Non-Discrimination All qualified applicants will receive consideration for employment without regard to sex, race, ethnicity, color, age, national origin, citizenship, religion, physical or mental disability, medical condition, genetic information, pregnancy, family structure, marital status, ancestry, domestic partner status, sexual orientation, gender identity or expression, veteran or military status, or any other basis prohibited by law. Leidos will also consider for employment qualified applicants with criminal histories consistent with relevant laws. Pay and Benefits Pay and benefits are fundamental to any career decision. That's why we craft compensation packages that reflect the importance of the work we do for our customers. Employment benefits include competitive compensation, Health and Wellness programs, Income Protection, Paid Leave and Retirement. More details are available here 93,800.00 - 134,285.00 USD The posted pay range for this job is a general guideline and not a guarantee of compensation or salary. Additional factors considered in extending an offer include, but are not limited to, responsibilities of the job, education, experience, knowledge, skills, and abilities as well as internal equity, and alignment with market data. The salary range posted is a full-time equivalent salary and will vary depending on scheduled hours for part time positions

Keywords: Frederick National Laboratory for Cancer Research, Montgomery Village , Associate Scientist - Mass Spectrometry Proteomics, Science, Research & Development , Frederick, Maryland